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Videos de Conceptos Relacionados

Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...

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Video Experimental Relacionado

Updated: May 16, 2026

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets
03:37

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

Modelado de la dinámica del transcriptoma en un mundo complejo.

Philipp A Jaeger1, Colleen Doherty, Trey Ideker

  • 1Departments of Medicine and Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.

Cell
|December 11, 2012
PubMed
Resumen
Este resumen es generado por máquina.

Los científicos ahora pueden predecir los cambios en la expresión génica del arroz debido a factores ambientales. Este avance en el modelado de respuestas transcripcionales ofrece el potencial para predecir respuestas en otros organismos en condiciones reales.

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Área de la Ciencia:

  • La genómica es la genómica.
  • Ciencias ambientales Ciencias ambientales.
  • Biología Vegetal Biología Vegetal

Sus antecedentes:

  • Predecir los cambios en la expresión génica de los estímulos ambientales es un desafío complejo.
  • Comprender estas respuestas es crucial para la agricultura y la ecología.

Objetivo del estudio:

  • Desarrollar un modelo para predecir los cambios de expresión de ARNm de todo el genoma en el arroz bajo diferentes condiciones ambientales.
  • Avanzar en la capacidad de pronosticar respuestas transcripcionales en organismos expuestos a entornos no controlados.

Principales métodos:

  • Utilizó técnicas avanzadas de modelado computacional.
  • Se analizaron datos de expresión de ARNm de todo el genoma de arroz sometido a diversos estímulos ambientales.

Principales resultados:

  • Modelado con éxito cambios en la expresión de ARNm de todo el genoma en el arroz.
  • Demostró la viabilidad de predecir las respuestas transcripcionales a las variables ambientales.

Conclusiones:

  • El trabajo de Nagano y sus colegas ofrece un avance significativo en la biología predictiva.
  • Esta investigación es prometedora para predecir la expresión génica en varios organismos en entornos del mundo real.