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Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
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Los cánceres impulsados por la β-catenina requieren un complejo transcripcional YAP1 para la supervivencia y la

Joseph Rosenbluh1, Deepak Nijhawan, Andrew G Cox

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

Cell
|December 19, 2012
PubMed
Resumen

La beta-catenina oncogénica (β-catenina) impulsa el cáncer al formar un complejo con YAP1 y TBX5.5. La inhibición de la quinasa YES1 interrumpe este complejo, deteniendo el crecimiento de los cánceres dependientes de la β-catenina.

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