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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response01:28

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
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Video Experimental Relacionado

Updated: May 15, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Neutralizando la inflamación crónica que promueve el tumor: ¿una bala mágica?

Lisa M Coussens1, Laurence Zitvogel, A Karolina Palucka

  • 1Department of Cell and Developmental Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239-3098, USA. coussenl@ohsu.edu

Science (New York, N.Y.)
|January 19, 2013
PubMed
Resumen

Las terapias recientes contra el cáncer se dirigen a las aberraciones genéticas y la vascularización tumoral. Los nuevos inmunoterapéuticos aprovechan la comprensión de que ciertas células inmunes promueven el crecimiento tumoral, ofreciendo nuevas estrategias para combatir la inflamación asociada al cáncer.

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Área de la Ciencia:

  • Oncología Oncología.
  • Inmunología Inmunología.
  • Investigación del cáncer Investigación del cáncer.

Sus antecedentes:

  • Los diagnósticos y las terapias contra el cáncer han avanzado significativamente en la última década.
  • Los tratamientos actuales incluyen quimioterapia, radiación, dirigirse a los mediadores intrínsecos de las células cancerosas y modular las vías extrínsecas de las células cancerosas.
  • Han surgido inmunoterápicos, reconociendo el papel de las células inmunes activadas crónicamente en el fomento del desarrollo de tumores.

Objetivo del estudio:

  • Revisar estudios clínicos y experimentales sobre las funciones protumorígenas de las células inmunes en la inflamación asociada al cáncer.
  • Para discutir el potencial de dirigirse a estas células inmunes para reprogramar su función.
  • Explorar cómo la reprogramación de las células inmunes puede neutralizar la inflamación crónica y facilitar el rechazo del cáncer.

Principales métodos:

  • Revisión de los estudios clínicos.
  • Análisis de estudios experimentales. análisis de estudios experimentales.
  • Delimitación de las funciones protumorígenas de los subconjuntos de células inmunes.
  • Discusión de las estrategias de orientación para la reprogramación de las células inmunes.

Principales resultados:

  • Identificó subconjuntos específicos de células inmunes que desempeñan funciones protumorígenas en la inflamación asociada al cáncer.
  • Se destacó que estas células inmunes pueden ser dirigidas para alterar su función.
  • Se demostró que la reprogramación de estas células puede resolver o neutralizar la inflamación que promueve el cáncer.

Conclusiones:

  • Dirigirse a los subconjuntos de células inmunes involucradas en la inflamación crónica ofrece una estrategia terapéutica prometedora.
  • La reprogramación de estas células puede conducir a la resolución de la inflamación que promueve el cáncer.
  • Este enfoque facilita el rechazo del cáncer y mejora los resultados terapéuticos.