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En las alquinas terminales que pueden reaccionar con los nucleófilos de cisteína del sitio activo en las proteasas

Reggy Ekkebus1, Sander I van Kasteren, Yogesh Kulathu

  • 1Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Journal of the American Chemical Society
|February 8, 2013
PubMed
Resumen

Los investigadores desarrollaron una nueva sonda dirigida al sitio activo utilizando ubiquitina modificada (Ub) con un alquino. Esta sonda se dirige selectivamente a las enzimas de-ubiquitinación, revelando nuevos conocimientos sobre la función enzimática y las interacciones de las proteínas.

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