Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

6.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
6.2K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.9K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.9K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

11.6K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
11.6K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.7K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

865
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
865

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Identification of cross-stage, cross-species malaria CD8<sup>+</sup> T cell antigens.

Nature·2026
Same author

Bivalent virus-like particles expressing SPECT1 and CSP trigger pre-erythrocytic malaria immunity and protect against transgenic <i>Plasmodium falciparum</i> sporozoite challenge in mice.

Frontiers in immunology·2026
Same author

Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults.

Wellcome open research·2026
Same author

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children.

Nature communications·2026
Same author

Recent Advances, Bottlenecks, and Future Directions in <i>Plasmodium falciparum</i> Vaccine Development.

Vaccines·2026
Same author

B and T cell responses to pre-erythrocytic R21/Matrix-M and blood-stage RH5.1/Matrix-M malaria vaccines in endemic settings.

Frontiers in immunology·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: May 5, 2026

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat
06:03

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat

Published on: September 20, 2016

13.2K

Identificar las adaptaciones recientes en los datos genómicos a gran escala.

Sharon R Grossman1, Kristian G Andersen, Ilya Shlyakhter

  • 1Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. grossman@broadinstitute.org

Cell
|February 19, 2013
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores identificaron variantes genéticas vinculadas a la adaptación humana mediante el análisis de datos del genoma. Encontraron variantes específicas que influyen en los rasgos y la susceptibilidad a las enfermedades, incluida una en el receptor tipo Toll 5 (TLR5) que afecta la señalización inmune.

Más Videos Relacionados

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.2K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.2K

Videos de Experimentos Relacionados

Last Updated: May 5, 2026

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat
06:03

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat

Published on: September 20, 2016

13.2K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.2K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.2K

Área de la Ciencia:

  • La genómica humana es la genómica humana.
  • Biología evolutiva Biología evolutiva.
  • Genética de la población Genética de la población.

Sus antecedentes:

  • Cientos de regiones del genoma humano muestran una selección natural positiva.
  • Sin embargo, los rasgos adaptativos específicos y las variantes genéticas siguen siendo en gran medida desconocidos.

Objetivo del estudio:

  • Identificar y anotar las variantes causales candidatas asociadas con la selección natural positiva en el genoma humano.
  • Para crear un catálogo de variantes para la validación experimental.

Principales métodos:

  • Se utilizaron datos de variación de la secuencia del genoma completo del Proyecto 1000 Genomas (1000G).
  • Empleó la prueba compuesta de múltiples señales (CMS) para analizar 412 señales candidatas.
  • Anotación funcional integrada, modelado de la estructura de las proteínas, epigenética y estudios de asociación.

Principales resultados:

  • Generó un catálogo de 35 variantes no sinónimas de alto puntaje y 59 variantes que afectan la expresión génica (gen codificante o lincRNA).
  • Se identificaron numerosas variantes asociadas con la susceptibilidad a enfermedades infecciosas y otros fenotipos.
  • Validación experimental de una variante no sinónima en el receptor tipo Toll 5 (TLR5), que demuestra una señalización alterada de NF-κB.

Conclusiones:

  • El estudio proporciona un valioso recurso de variantes adaptativas candidatas para futuras investigaciones.
  • Los hallazgos ponen de relieve el papel de las variantes genéticas específicas en la adaptación humana y la enfermedad.
  • La caracterización experimental de la variante TLR5 confirma su impacto funcional en la respuesta inmune.