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Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Hidro-aminometilación eficiente y regioselectiva catalizada por rutenio de las olefinas
Lipeng Wu1, Ivana Fleischer, Ralf Jackstell
1Leibniz-Institut für Katalyse e.V., an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany.
Journal of the American Chemical Society
|February 20, 2013
Resumen
Los catalizadores de rutenio con nuevos ligandos fosfino-imidazol convierten eficientemente las olefinas y aminas en valiosas aminas secundarias y terciarias. Esta reacción de hidroaminometilación ofrece altos rendimientos y una excelente regioselectividad para diversos sustratos.
Área de la Ciencia:
- Química orgánica es la química orgánica.
- La catálisis de la catálisis.
- Química organometálica Química orgánica de los metales.
Sus antecedentes:
- La hidroaminometilación es una reacción crucial para la síntesis de aminas.
- El desarrollo de sistemas catalíticos eficientes y regioselectivos sigue siendo un desafío.
Objetivo del estudio:
- Informar de una nueva hidroaminometilación catalizada por rutenio de las olefinas.
- Para lograr altos rendimientos y regioselectividad utilizando ligandos y catalizadores específicos.
Principales métodos:
- Utilizando el dodecacarbonilo de trirutenio como el precursor del catalizador.
- Utilizando ligandos específicos de imidazol sustituidos por 2-fosfino.
- Reaccionan varias olefinas alifáticas y funcionalizadas con aminas primarias y secundarias.
Principales resultados:
- Se obtienen rendimientos generalmente altos (hasta el 96%) para aminas secundarias y terciarias.
- Se han demostrado excelentes selectividades regionales (proporciones n/iso de hasta 99:1).
- El sistema catalítico demostró ser eficaz tanto para las olefinas simples como para las funcionalizadas.
Conclusiones:
- La hidroaminometilación catalizada por rutenio desarrollada es un método eficiente y regioselectivo.
- El uso de ligandos de imidazol sustituidos por 2-fosfino es clave para el éxito de la reacción.
- Este método proporciona una vía valiosa para sintetizar diversas aminas a partir de materiales de partida fácilmente disponibles.
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