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Asociación del estado materno de vitamina D durante el embarazo con el contenido de minerales óseos en la
Debbie A Lawlor1, Andrew K Wills, Abigail Fraser
1MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol UK. d.a.lawlor@bristol.ac.uk
Lancet (London, England)
|March 23, 2013
Resumen
Los niveles maternos de vitamina D durante el embarazo no afectaron el contenido mineral óseo de la descendencia en la infancia tardía. Este gran estudio no encontró una asociación significativa entre el estado maternal de 25 ((OH) D y la salud ósea de los niños.
Área de la Ciencia:
- Fisiología Humana Fisiología Humana.
- Ciencias de la Nutrición Ciencias de la Nutrición
- Salud Pediátrica en la Salud Pediátrica.
Sus antecedentes:
- Se supone que el estado materno de vitamina D durante el embarazo influye en el contenido mineral óseo (CMB) de la descendencia.
- Las investigaciones anteriores sobre esta asociación han estado limitadas por el pequeño tamaño de los estudios.
- Este estudio investiga el vínculo en una cohorte grande y prospectiva.
Objetivo del estudio:
- Examinar la asociación entre las concentraciones séricas maternas de 25-hidroxivitamina D [25(OH) D] durante el embarazo y el CMI de la descendencia a la edad de 9-10 años.
- Para determinar si el estado materno de vitamina D en diferentes trimestres afecta el desarrollo óseo de la descendencia.
Principales métodos:
- Se utilizaron datos del Estudio Longitudinal Avon de Padres e Hijos, que incluyó 3960 parejas madre-hijo.
- Se midieron los niveles maternos de 25 ((OH) D durante el embarazo y la descendencia de cuerpo total menos cabeza (TBLH) y CMI espinal a través de absorptiometría de rayos X de doble energía.
- Se clasificó el 25(OH) D materno como suficiente (>50.00 nmol/L), insuficiente (27.50-49.99 nmol/L), o con deficiencia (<27.50 nmol/L).
Principales resultados:
- No se observaron diferencias significativas en la TBLH o la CMI espinal entre los hijos de madres con niveles suficientes, insuficientes o deficientes de vitamina D.
- El análisis a lo largo de los trimestres de embarazo, incluido el tercer trimestre, no reveló ninguna asociación con la CMI de la descendencia.
- Las diferencias medias ajustadas por confusión para TBLH y CMI espinal por cada 10,0 nmol/L de aumento en la DMO materna fueron insignificantes.
Conclusiones:
- El estado materno de vitamina D durante el embarazo no es un determinante significativo del contenido mineral óseo de la descendencia en la infancia tardía.
- Estos hallazgos sugieren que las intervenciones que se centran únicamente en la vitamina D materna para mejorar la salud ósea infantil pueden no ser efectivas.
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