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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
Paisajes del genoma del cáncer paisajes del genoma del cáncer
Bert Vogelstein1, Nickolas Papadopoulos, Victor E Velculescu
1The Ludwig Center and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.
Science (New York, N.Y.)
|March 30, 2013
Resumen
La secuenciación del genoma del cáncer revela ~ 140 genes impulsores que promueven el crecimiento tumoral. Comprender estos genes y sus vías es crucial para desarrollar nuevos tratamientos contra el cáncer y reducir la mortalidad.
Área de la Ciencia:
- La genómica es la genómica.
- Biología del cáncer Biología del cáncer.
- Oncología Molecular Oncología Molecular
Sus antecedentes:
- La secuenciación completa del genoma del cáncer ha identificado las alteraciones genéticas subyacentes a los cánceres humanos comunes.
- Los genomas del cáncer presentan algunos genomas con frecuencia mutados.
- Montañas montañas montañas.
- y muchos raramente mutados.
- Las colinas las colinas.
- Los genes. los genes.
Objetivo del estudio:
- Identificar y clasificar los genes impulsores del cáncer y sus vías de señalización asociadas.
- Para resaltar la importancia de comprender estas vías para la futura investigación del cáncer y el desarrollo terapéutico.
Principales métodos:
- Análisis de conjuntos de datos genómicos de cáncer a gran escala.
- Identificación de genes con mutaciones intragénicas que promueven la tumorigénesis.
- Clasificación de los genes conductores en las vías de señalización que regulan los procesos celulares centrales.
Principales resultados:
- Se han identificado aproximadamente 140 genes conductores que promueven la tumorigénesis a través de mutaciones intragénicas.
- Un tumor típico alberga de dos a ocho mutaciones del gen conductor, y otras son mutaciones pasajeras.
- Los genes conductores están organizados en 12 vías de señalización que gobiernan el destino celular, la supervivencia y el mantenimiento del genoma.
Conclusiones:
- El conocimiento actual de los genomas del cáncer es suficiente para informar el desarrollo de terapias mejoradas contra el cáncer.
- Comprender los genes y las vías de conducción del cáncer es esencial para reducir la morbilidad y la mortalidad por cáncer.
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