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Updated: May 12, 2026

Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures
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Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures

Published on: May 9, 2020

Básico estructural de la inhibición de la kynurenina 3-monooxigenasa

Marta Amaral1, Colin Levy, Derren J Heyes

  • 1Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

Nature
|April 12, 2013
PubMed
Resumen

La inhibición de la kynurenina 3-monooxigenasa (KMO) muestra un potencial terapéutico para las enfermedades neurodegenerativas. La primera estructura cristalina de KMO revela cómo se unen los inhibidores, lo que permite el diseño de fármacos basados en la estructura para afecciones como el Alzheimer y el Parkinson.

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