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Deterioro del desarrollo en la regeneración neuronal por el cambio progresivo de dos temporizadores intrínsecos
Yan Zou1, Hui Chiu1, Anna Zinovyeva2
1Division of Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio 45229.
Science (New York, N.Y.)
|April 20, 2013
Resumen
Envejecimiento Las neuronas de Caenorhabditis elegans pierden la capacidad de regeneración de axones debido al microARN let-7 que inhibe LIN-41. Este circuito let-7-LIN-41 recíproco asegura que la regeneración se bloquee sólo en las neuronas más viejas.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología Molecular Biología Molecular
- Genética La genética.
Sus antecedentes:
- La capacidad de regeneración de los axones disminuye con la edad tanto en las neuronas de mamíferos como en las de Caenorhabditis elegans.
- Los mecanismos moleculares subyacentes para esta pérdida de regeneración dependiente de la edad no se comprenden completamente.
Objetivo del estudio:
- Para investigar el papel del microARN let-7 en el deterioro relacionado con la edad de la regeneración del axón del microtúbulo ventral anterior (AVM) en Caenorhabditis elegans.
- Para dilucidar el circuito regulador que controla la regeneración de los axones en las neuronas de envejecimiento.
Principales métodos:
- Análisis de la función let-7 del microARN en el envejecimiento de las neuronas de Caenorhabditis elegans.
- Investigando la interacción entre let-7 y la proteína LIN-41.
- Utilizando la región 3' no traducida de lin-41 y Argonaute ALG-1 en mecanismos regulatorios.
Principales resultados:
- let-7 microRNA inhibe la regeneración del axón AVM en las neuronas más viejas mediante la regulación a la baja de LIN-41, un factor que promueve la regeneración.
- Existe un circuito inhibidor recíproco: let-7 inhibe lin-41 en las neuronas más viejas, mientras que LIN-41 inhibe let-7 en las neuronas más jóvenes a través de Argonaute ALG-1.
- Este circuito asegura que la regeneración de los axones se inhibe específicamente en las neuronas más viejas.
Conclusiones:
- Un circuito regulador let-7-LIN-41 se reutiliza en las neuronas postmitóticas para controlar los eventos posteriores a la diferenciación, específicamente la regeneración de los axones.
- Este mecanismo molecular explica la disminución dependiente de la edad en la regeneración de axones observada en Caenorhabditis elegans.
- Los hallazgos destacan los mecanismos reguladores conservados en diferentes tipos de células y etapas de desarrollo.
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