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Las neuronas corticostriatales en la corteza auditiva impulsan las decisiones durante la discriminación auditiva

Petr Znamenskiy¹, Anthony M Zador

¹Watson School of Biological Sciences, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

|May 3, 2013

Resumen

Los investigadores exploraron cómo el cerebro transforma la información sonora en acciones utilizando una tarea de toma de decisiones de rata. La manipulación de las neuronas corticostriatales influyó en las elecciones auditivas, revelando su papel en las transformaciones sensorio-motoras.

Área de la Ciencia:

La neurociencia es la neurociencia.
La percepción auditiva es la percepción auditiva.
Tomar una decisión de toma de decisiones.

Sus antecedentes:

Se comprenden las vías neuronales que transmiten información auditiva a la corteza.
El mecanismo para convertir las representaciones auditivas en comandos motores sigue sin estar claro.

Objetivo del estudio:

Investigar la transformación de la información auditiva en comandos motores.
Para aclarar el papel de las neuronas de proyección corticostriatal en la toma de decisiones auditivas.

Principales métodos:

Utilizó una tarea de toma de decisiones perceptiva en ratas que implicaba discriminación de frecuencia auditiva.
Estimulación mediada por canal rodopsina-2 (ChR2) y inactivación mediada por arquerodopsina-3 (Arc) de las neuronas corticostriatales empleadas.

Principales resultados:

La estimulación de las neuronas corticostriatales sesgaba las decisiones de acuerdo con su sintonía de frecuencia.
La inactivación de estas neuronas condujo a sesgos de decisión opuestos.
Demostró un vínculo causal entre la actividad corticostriatal y las elecciones auditivas.

Conclusiones:

Las neuronas de proyección corticostriatal juegan un papel crítico en la toma de decisiones auditivas.
Estas neuronas median la transformación de la información sensorial en comandos motores.
Las proyecciones estriadas generalizadas sugieren un mecanismo general para el control de la corteza sensorial de las decisiones motoras.

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