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The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
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The human need for self-esteem has long intrigued psychologists, leading to the development of several theories that explore its evolutionary and functional significance. Among the most influential are the sociometer, hierometer, and terror management theories. Each offers a unique perspective on why people strive for self-worth and how it shapes behavior and social interaction.Sociometer TheoryAccording to sociometer theory, self-esteem functions as an internal gauge of social acceptance. It...
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Joven en el corazón.

Leslie A Leinwand1, Brooke C Harrison

  • 1Department of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA. leslie.leinwand@colorado.edu

Cell
|May 14, 2013
PubMed
Resumen
Este resumen es generado por máquina.

La circulación sanguínea de ratones jóvenes puede revertir la hipertrofia cardíaca en ratones viejos. Este efecto se replica mediante el tratamiento de ratones viejos con el factor de diferenciación del crecimiento 11 (GDF11), lo que sugiere la terapia GDF11 para afecciones cardíacas relacionadas con la edad.

Área de la Ciencia:

  • Gerontología y Medicina Regenerativa.
  • Biología Cardiovascular Biología Cardiovascular

Sus antecedentes:

  • El envejecimiento está asociado con cambios perjudiciales en la estructura y función cardíaca, incluida la hipertrofia cardíaca.

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  • La hipertrofia cardíaca relacionada con la edad perjudica la función cardíaca y aumenta el riesgo de enfermedades cardiovasculares.