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La inhibición de moléculas pequeñas de la interacción KRAS-PDEδ afecta la señalización oncogénica de KRAS

Gunther Zimmermann1, Björn Papke, Shehab Ismail

  • 1Department of Chemical Biology, Max Planck Institute of Molecular Physiology, D-44227 Dortmund, Germany.

Nature
|May 24, 2013
PubMed
Resumen

Los investigadores desarrollaron pequeñas moléculas que interrumpen la interacción KRAS-PDEδ, ofreciendo una nueva estrategia para inhibir la señalización RAS oncogénica y suprimir la proliferación de células de cáncer de páncreas.

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