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Ligand Binding and Linkage

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked. In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...

Ligand Binding and Linkage

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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked. In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
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Updated: May 10, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

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Published on: January 14, 2020

Bibliotecas combinatorias dinámicas: desde la exploración del reconocimiento molecular hasta la química de sistemas.

Jianwei Li¹, Piotr Nowak, Sijbren Otto

¹Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Journal of the American Chemical Society

|June 5, 2013

Resumen

Este resumen es generado por máquina.

La química combinatoria dinámica (DCC, por sus siglas en inglés) utiliza moléculas interconvertidas para descubrir nuevas estructuras como los autorreplicadores. Este enfoque, las bibliotecas dinámicas combinatorias (DCL), ofrece nuevas vías en la química de sistemas y las máquinas moleculares.

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Área de la Ciencia:

Química Química es la química.
Química supramolecular de las moléculas.
Química de sistemas Química de sistemas

Sus antecedentes:

La química combinatoria dinámica (DCC) involucra bibliotecas donde los miembros intercambian continuamente bloques de construcción.
Las bibliotecas combinatorias dinámicas (DCL) son clave para descubrir estructuras y funciones moleculares inesperadas.
Las DCL permiten propiedades emergentes en redes moleculares, abriendo nuevas posibilidades en la química de sistemas.

Objetivo del estudio:

Para resaltar las nuevas metodologías en química dinámica combinatoria.
Para analizar DCL bajo control termodinámico para aplicaciones en síntesis y autoensamblaje.
Revisar las extensiones de los principios de DCC a los sistemas de no equilibrio para funcionalidades avanzadas.

Principales métodos:

Exploración de la interconversión dinámica de los miembros de la biblioteca química.
Control termodinámico de las bibliotecas dinámicas combinatorias.
Aplicación de los principios de DCC a los sistemas de no equilibrio.

Principales resultados:

Descubrimiento de nuevas moléculas, incluyendo estructuras entrelazadas y autorreplicantes.
Desarrollo de receptores sintéticos, sistemas catalíticos y arquitecturas supramoleculares.
Demostración de un comportamiento funcional más rico en sistemas de no equilibrio, como la autorreplicación y las máquinas moleculares.

Conclusiones:

Las DCL son potentes herramientas para el descubrimiento molecular y la química de sistemas.
El control termodinámico en DCLs produce diversos sistemas funcionales.
La extensión de DCC a los sistemas de no equilibrio desbloquea funcionalidades moleculares avanzadas.