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Reclutamiento dependiente del comportamiento de neuronas de proyección de largo alcance en la corteza somatosensorial
Jerry L Chen1, Stefano Carta, Joana Soldado-Magraner
1Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Nature
|June 25, 2013
Resumen
Las vías neuronales en el cerebro del ratón transmiten información sensorial de manera diferente según el comportamiento. Neuronas de proyección distintas en la corteza somatosensorial primaria (S1) envían selectivamente datos relacionados con los bigotes a las áreas motoras y de asociación.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- El procesamiento sensorial es el procesamiento sensorial.
- Los circuitos corticales son los circuitos corticales.
Sus antecedentes:
- El neocórtex de los mamíferos se basa en corrientes de procesamiento segregadas para la representación sensorial.
- La transmisión de información local desde la corteza sensorial primaria a áreas distantes durante el comportamiento sigue siendo poco comprendida.
Objetivo del estudio:
- Investigar la activación dependiente de la tarea de las neuronas de proyección en la corteza somatosensorial primaria (S1) durante el comportamiento.
- Determinar cómo la información se transmite selectivamente desde S1 a la corteza somatosensorial secundaria (S2) y a la corteza motora primaria (M1).
Principales métodos:
- Imágenes de calcio de dos fotones en ratones despiertos y con comportamiento que realizan tareas de discriminación de texturas y detección de objetos.
- Monitoreo de la actividad neuronal en las neuronas S1 identificadas anatómicamente que se proyectan hacia S2 o M1.
- Analizar las respuestas dependientes de la tarea y las capacidades discriminativas de las neuronas de proyección S2 (S2P) y M1 (M1P).
Principales resultados:
- Se identificaron células relacionadas con el whisking en las neuronas S2P, pero no en las M1P.
- Las neuronas S2P mostraron más respuestas al tacto durante la discriminación de texturas; las neuronas M1P mostraron más durante la detección de ubicación.
- Tanto las neuronas S2P como las M1P discriminaban las decisiones de comportamiento de manera similar, pero las neuronas S2P sobresalían en la discriminación de textura y las neuronas M1P en la discriminación de ubicación cuando las decisiones eran las mismas.
Conclusiones:
- La transmisión selectiva de información de S1 a S2 y M1 está impulsada por el contexto conductual, no solo por características sensoriales.
- Las distintas poblaciones de neuronas de proyección en S1 desempeñan funciones especializadas en la transmisión de información sensorial para diferentes objetivos de comportamiento.
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