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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
Published on: January 17, 2020
Ingeniería quiral polioxometalato híbrido metal-orgánico marcos para la dihidroxilación asimétrica de las olefinas
Qiuxia Han1, Cheng He, Min Zhao
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People's Republic of China.
Journal of the American Chemical Society
|June 29, 2013
Resumen
Las estructuras quirales metal-orgánicas (MOF) funcionan como catalizadores heterogéneos asimétricos efectivos. Estos nuevos Ni-PYI MOF demuestran una alta estereoselectividad en la catalización de la dihidroxilación asimétrica de las olefinas de arilo.
Área de la Ciencia:
- Ciencia de los materiales Ciencia de los materiales.
- La catálisis es la catálisis.
- Química orgánica es la química orgánica.
Sus antecedentes:
- Las estructuras quirales metal-orgánicas (MOF) son catalizadores heterogéneos asimétricos versátiles.
- Su naturaleza porosa y ajustable permite diversas reacciones químicas.
Objetivo del estudio:
- Desarrollar nuevos MOFs quirales que incorporen catalizadores de oxidación y grupos quirales.
- Para investigar su eficacia en reacciones de dihidroxilación asimétricas.
Principales métodos:
- Autoensamblaje de dos enantiomorfos, Ni-PYI1 y Ni-PYI2, mediante el uso de [BW12O40](5-) y L- o D-pirrolidina-2-ilimidazol (PYI).
- Reacción de intercambio de invitados para agrandar los canales MOF y modular las propiedades hidrofílicas / hidrofóbicas.
- Prueba de los MOF como catalizadores para la dihidroxilación asimétrica de las olefinas de arilo.
Principales resultados:
- Los Ni-PYIs sintetizados exhibieron propiedades de canal moduladas para la entrada / salida de reactivos.
- El espacio confinado dentro de los MOFs facilitó la formación estereoselectiva de productos intermedios de reacción.
- El catalizador MOF anfipático logró una excelente estereoselectividad en la dihidroxilación asimétrica.
Conclusiones:
- Los MOFs quirales desarrollados sirven como eficientes catalizadores anfipáticos.
- Permiten la dihidroxilación asimétrica altamente estereoselectiva de las olefinas de arilo.
- Este trabajo amplía la aplicación de MOFs quirales en la catálisis.
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