Search research articles

ACERCA DE JoVE

Visión General Liderazgo Blog Centro de Ayuda JoVE

AUTORES

Proceso de Publicación Consejo Editorial Alcance y Políticas Revisión por Pares Preguntas Frecuentes Enviar

BIBLIOTECARIOS

Testimonios Suscripciones Acceso Recursos Consejo Asesor de Bibliotecas Preguntas Frecuentes

INVESTIGACIÓN

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archivo

EDUCACIÓN

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Centro de Recursos para Profesores Sitio de Profesores

Términos y Condiciones de Uso

Política de Privacidad

Videos de Conceptos Relacionados

Cholecystitis

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

Chronic Pancreatitis II: Pathophysiology

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por

Same author

More Levels of Complexity in the Control of Intestinal Inflammation.

Cellular and molecular gastroenterology and hepatology·2021

Same author

EASL recognition award recipient 2021: Prof. Patrizia Burra.

Journal of hepatology·2021

Same author

Outcomes of Prosthesis-Patient Mismatch Following Supra-Annular Transcatheter Aortic Valve Replacement: From the STS/ACC TVT Registry.

JACC. Cardiovascular interventions·2021

Same author

Mitral Surgery After Transcatheter Edge-to-Edge Repair: Society of Thoracic Surgeons Database Analysis.

Journal of the American College of Cardiology·2021

Same author

Sinusoidal Endothelial Cells as Orchestrators of the Gut Liver Immune Axis.

Hepatology (Baltimore, Md.)·2021

Same author

Anatomic classification of mitral annular calcification for surgical and transcatheter mitral valve replacement.

Journal of cardiac surgery·2021

Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026

Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026

Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026

Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026

Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026

Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026

Ver todos los artículos relacionados

Search research articles

Video Experimental Relacionado

Updated: May 10, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Colangitis esclerosante primaria La colangitis esclerosante primaria es una enfermedad de la colangitis esclerosante

Gideon M Hirschfield¹, Tom H Karlsen, Keith D Lindor

¹Centre for Liver Research, National Institute for Health Research Biomedical Research Unit, University of Birmingham, Birmingham, UK.

Lancet (London, England)

|July 2, 2013

Resumen

Este resumen es generado por máquina.

La colangitis esclerosante primaria (CSP) es una enfermedad hepática crónica relacionada con la enfermedad inflamatoria intestinal (EII). Los tratamientos actuales son de apoyo, pero la investigación en patobiología puede ofrecer nuevas terapias.

Videos de Experimentos Relacionados

Last Updated: May 10, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Área de la Ciencia:

Hepatología Hepatología.
Gastroenterología y Gastroenterología.
Inmunología Inmunología.

Sus antecedentes:

La colangitis esclerosante primaria (CSP) es una complicación hepática significativa de la enfermedad inflamatoria intestinal (EII).
La CPS se caracteriza por una colestasis crónica y progresiva, que a menudo conduce a cirrosis biliar y enfermedad hepática en etapa terminal.
Los riesgos de cáncer hepatobiliar y colorrectal son elevados en pacientes con EII y CFP coexistentes.

Objetivo del estudio:

Revisar la presentación clínica, la progresión y el manejo de la CPS.
Explorar los conocimientos mecanicistas de la colangitis esclerosante secundaria y los estudios genómicos.
Para resaltar la necesidad de comprender los factores ambientales en la patogénesis de la PSC.

Principales métodos:

Revisión de la literatura existente sobre la colangitis esclerosante primaria y la enfermedad inflamatoria intestinal.
Análisis de perfiles clínicos y estudios genómicos.
Exploración de los mecanismos inmunológicos en el daño del árbol biliar.

Principales resultados:

PSC es una enfermedad hepática crónica y progresiva asociada con EII, sin tratamientos médicos efectivos para retrasar la progresión.
A menudo se requiere un trasplante de hígado, pero la recurrencia de la enfermedad es un riesgo.
El aumento de la incidencia de cáncer (hepatobiliar y colorrectal) es una gran preocupación.

Conclusiones:

El tratamiento actual para la PSC es de apoyo, enfatizando la necesidad de nuevas estrategias terapéuticas.
Comprender el papel de los factores ambientales y las respuestas inmunes es crucial para el desarrollo de tratamientos futuros.
Los avances en la patobiología sugieren el potencial de nuevos enfoques de tratamiento estratificado para la CPS.