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Las capas corticales profundas son activadas directamente por el tálamo
Christine M Constantinople1, Randy M Bruno
1Department of Neuroscience and Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA.
Science (New York, N.Y.)
|July 2, 2013
Resumen
La información sensorial llega a la corteza a través de sinapsis talamocorticales (TC) directas a las capas profundas (L5 / 6), no solo a través de la capa 4 (L4). Esto revela corrientes de procesamiento paralelo en el cerebro.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Los circuitos corticales son circuitos corticales.
- El procesamiento sensorial es el procesamiento sensorial.
Sus antecedentes:
- La proyección talamocortical (TC) es la vía principal para la información sensorial a la corteza.
- Se creía ampliamente que la información sensorial se propaga desde la capa 4 (L4) a otras capas corticales (L2/3, L5/6).
Objetivo del estudio:
- Para investigar la entrada sináptica directa desde el tálamo a las capas corticales profundas (L5/6).
- Para determinar si la capa 4 (L4) es un relé obligatorio para la información sensorial a las neuronas L5 / 6.
Principales métodos:
- Registros electrofisiológicos in vivo en ratas.
- Grabaciones emparejadas de las neuronas tálamicas y L5/6.
- La inactivación farmacológica de la capa 4 (L4).
Principales resultados:
- Muchas neuronas L5/6 mostraron entrada sináptica TC directa con latencias similares a las respuestas L4.
- Convergencia sustancial de las sinapsis directas de TC en varias neuronas infragranulares, especialmente en L5B.
- La inactivación de L4 no afectó la entrada sináptica evocada sensorialmente a las neuronas L5 / 6.
Conclusiones:
- La capa 4 (L4) no es un centro de distribución obligatorio para la actividad cortical sensorial.
- El tálamo activa corrientes de procesamiento cortical separadas y paralelas, dirigiéndose directamente a las neuronas L4 y L5/6.
- Esto desafía la visión tradicional del flujo jerárquico de información dentro de la corteza.
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