Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

The Extracellular Matrix01:42

The Extracellular Matrix

65.0K
Overview
65.0K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
1.9K
The Extracellular Matrix01:29

The Extracellular Matrix

10.7K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
10.7K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

8.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
8.0K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K
Extracellular Matrix01:26

Extracellular Matrix

5.9K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.9K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography.

bioRxiv : the preprint server for biology·2024
Same author

Export of Diverse and Bioactive Small Proteins through a Type I Secretion System.

Applied and environmental microbiology·2023
Same author

Export of diverse and bioactive peptides through a type I secretion system.

bioRxiv : the preprint server for biology·2023
Same author

Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity.

The Biochemical journal·2022
Same author

Changes in the Fitness Fatness Index following reduced exertion high-intensity interval training versus moderate-intensity continuous training in physically inactive adults.

Frontiers in sports and active living·2022

Video Experimental Relacionado

Updated: May 5, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

9.9K

Juntando las piezas del rompecabezas extracelular.

Daniel J Leahy1

  • 1Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. dleahy@jhmi.edu

Cell
|July 6, 2013
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores desarrollaron un nuevo ensayo de alto rendimiento para identificar las interacciones de proteínas extracelulares. Este método descubrió con éxito numerosas nuevas interacciones en Drosophila, avanzando en los estudios de interacción de proteínas.

Más Videos Relacionados

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
09:40

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

19.3K
Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans
09:06

Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans

Published on: September 18, 2020

8.8K

Videos de Experimentos Relacionados

Last Updated: May 5, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

9.9K
A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
09:40

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

19.3K
Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans
09:06

Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans

Published on: September 18, 2020

8.8K

Área de la Ciencia:

  • La bioquímica es la bioquímica.
  • La genómica es la genómica.
  • La proteómica es la proteómica.

Sus antecedentes:

  • La identificación de las interacciones proteicas es crucial para comprender las funciones celulares.
  • Los métodos actuales de detección a gran escala son ineficientes para las proteínas extracelulares eucariotas.

Objetivo del estudio:

  • Desarrollar un ensayo de alto rendimiento específicamente para detectar las interacciones de proteínas extracelulares.
  • Para identificar nuevas interacciones de proteínas dentro de tres superfamilias en Drosophila.

Principales métodos:

  • Desarrollo de un nuevo ensayo de cribado de alto rendimiento.
  • Aplicación del ensayo para estudiar las interacciones de proteínas en Drosophila.

Principales resultados:

  • El ensayo identificó con éxito un número significativo de nuevas interacciones extracelulares de proteínas.
  • Se descubrieron nuevas interacciones entre las tres principales superfamilias de proteínas en Drosophila.

Conclusiones:

  • El ensayo desarrollado es eficaz para la identificación a gran escala de las interacciones de proteínas extracelulares.
  • Este trabajo proporciona una base para pantallas más completas de las interacciones de proteínas en Drosophila.