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Videos de Conceptos Relacionados

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Video Experimental Relacionado

Updated: May 10, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Published on: May 30, 2025

lincRNAs: genómica, evolución y mecanismos

Igor Ulitsky1, David P Bartel

  • 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Cell
|July 6, 2013
PubMed
Resumen

Los ARN no codificantes de larga intervención (ARNlinc) son abundantes en los genomas de los vertebrados y son cruciales para la regulación génica. Esta revisión explora su identificación, genómica, evolución y mecanismos de acción.

Área de la Ciencia:

  • La genómica es la genómica.
  • Biología Molecular Biología Molecular
  • Biología evolutiva Biología evolutiva.

Sus antecedentes:

  • Los ARN no codificantes de larga duración (ARNlinc) son una clase de transcripciones originadas en miles de loci dentro de los genomas de los mamíferos.
  • Estas moléculas son cada vez más reconocidas por su potencial para regular la expresión génica e influir en diversas funciones celulares.

Objetivo del estudio:

  • Revisar la comprensión actual de los lincRNA en animales vertebrados.
  • Para resaltar los métodos para identificar los lincRNAs.
  • Para discutir aspectos clave de la genómica del lincRNA, la evolución y los mecanismos de acción.

Principales métodos:

  • Revisión de la literatura de los estudios sobre los lincRNA en los vertebrados.

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  • Análisis de datos genómicos relacionados con el lincRNA loci.
  • Examen de la evidencia experimental para las funciones de lincRNA.

    • Principales resultados:

    • Los lincRNA están muy extendidos en los genomas de los vertebrados.
    • Varios enfoques computacionales y experimentales se utilizan para la identificación de lincRNA.
    • Los datos emergentes sugieren diversos roles en la regulación génica y los procesos celulares.

    Conclusiones:

    • El campo de la investigación del lincRNA está avanzando rápidamente, revelando sus importantes roles biológicos.
    • Se necesitan más investigaciones para aclarar completamente la genómica del lincRNA, las trayectorias evolutivas y los mecanismos precisos de acción.