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Una red de interacciones mediadas por cadherina polariza los conos de crecimiento para determinar la especificidad de
Tina Schwabe1, Helen Neuert, Thomas R Clandinin
1Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
Cell
|July 23, 2013
Resumen
Los axones fotorreceptores en Drosophila usan moléculas de adhesión celular redundantes, N-cadherin y Flamingo, para guiar sus conos de crecimiento. Esto asegura un cableado preciso del sistema visual a través de una red de interacciones adhesivas.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología del desarrollo Biología del desarrollo.
- Biología celular Biología celular.
Sus antecedentes:
- Los conos de crecimiento neuronal navegan por entornos complejos para encontrar socios sinápticos.
- Las señales adhesivas guían el movimiento del cono de crecimiento, pero los mecanismos de integración siguen sin estar claros.
Objetivo del estudio:
- Para investigar cómo los conos de crecimiento de fotorreceptores en Drosophila seleccionan socios sinápticos.
- Para aclarar los roles de N-cadherin y Flamingo en la orientación de la orientación de los axones de los fotorreceptores.
Principales métodos:
- Utilizó el sistema visual de Drosophila como modelo.
- Examinó la función de la cadherina clásica (N-cadherina) y la cadherina atípica (Flamingo).
- Se analizó la distribución de filopodia del cono de crecimiento y la localización subcelular de las cadherinas.
Principales resultados:
- La N-cadherina y el Flamingo actúan redundantemente para guiar la orientación de los axones de los fotorreceptores.
- Estas moléculas sesgan el crecimiento del cono filopodia, polarizándolos hacia objetivos sinápticos antes del contacto.
- Las cadherinas se localizan en dominios distintos, formando una red de interacciones adhesivas a través de múltiples conos de crecimiento.
Conclusiones:
- Las interacciones adhesivas redundantes mediadas por N-cadherin y Flamingo aseguran un cableado de alta fidelidad del sistema visual.
- Este mecanismo de red sugiere un principio general para el cableado neuronal.
- La selección precisa de la pareja sináptica se logra a través de señales adhesivas integradas.
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