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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Video Experimental Relacionado

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Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
09:33

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration

Published on: October 3, 2019

Interacciones tisulares en el desarrollo de células de la cresta neural y en la enfermedad.

Yoshiko Takahashi1, Douglas Sipp, Hideki Enomoto

  • 1Department of Zoology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan. yotayota@develop.zool.kyoto-u.ac.jp

Science (New York, N.Y.)
|August 24, 2013
PubMed
Resumen

Las células de la cresta neural (NCC) son células embrionarias vitales que forman el sistema nervioso periférico. Sus interacciones con otras células, señales ambientales y patógenos influyen en el desarrollo y enfermedades como el neuroblastoma.

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Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
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Área de la Ciencia:

  • Biología del desarrollo Biología del desarrollo.
  • Biología celular Biología celular.
  • La neurociencia es la neurociencia.

Sus antecedentes:

  • La cresta neural es una población celular embrionaria transitoria.
  • Las células de la cresta neural (NCC) se diferencian en diversos tipos de células, incluidos los componentes del sistema nervioso periférico.
  • Los NCC disfuncionales están vinculados a enfermedades como el neuroblastoma y la enfermedad de Hirschsprung.

Objetivo del estudio:

  • Para dilucidar las interacciones críticas que influyen en el comportamiento de las células de la cresta neural (NCC).
  • Comprender el papel de las interacciones de NCC en el desarrollo embrionario y la patogénesis de la enfermedad.
  • Para resaltar el impacto de las señales celulares y ambientales en el destino de NCC.

Principales métodos:

  • Revisión de estudios recientes sobre la migración y diferenciación de las NCC.
  • Análisis de las interacciones intercelulares que involucran NCC y linajes vasculares.
  • Examen de las señales ambientales y las influencias de los patógenos microbianos en los NCC.

Principales resultados:

  • Las interacciones del NCC con los linajes vasculares son cruciales para su desarrollo.
  • Las señales ambientales y los patógenos microbianos modulan significativamente las funciones del NCC.
  • La comprensión de estas interacciones proporciona información sobre las contribuciones de la NCC al desarrollo y la enfermedad.

Conclusiones:

  • Las interacciones entre los NCC y otros linajes celulares, los factores ambientales y los patógenos son determinantes clave de la función de los NCC.
  • Estas interacciones tienen implicaciones significativas tanto para el desarrollo embrionario normal como para la etiología de las enfermedades asociadas.
  • La investigación adicional sobre estas interacciones complejas puede informar las estrategias terapéuticas para los trastornos relacionados con el NCC.