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Lupus eritematoso sistémico y otras enfermedades reumáticas autoinmunes: desafíos para el tratamiento
Grainne Murphy1, Larissa Lisnevskaia, David Isenberg
1Centre for Rheumatology, Department of Medicine, University College London Hospital, London, UK.
Lancet (London, England)
|August 27, 2013
Resumen
Los avances en la comprensión de las enfermedades reumáticas autoinmunes han llevado a tratamientos biológicos dirigidos que mejoran los resultados de los pacientes. El belimumab, un inhibidor de las células B, es un ejemplo clave, con investigaciones en curso que exploran nuevas terapias para el lupus eritematoso sistémico.
Área de la Ciencia:
- Inmunología Inmunología.
- Reumatología Reumatología.
- Farmacología Farmacología.
Sus antecedentes:
- El creciente conocimiento de la patogénesis molecular en las enfermedades reumáticas autoinmunes.
- Desarrollo de tratamientos biológicos dirigidos que modulen las respuestas inmunes.
- Mejoras en la morbilidad y mortalidad debido a nuevas terapias.
Objetivo del estudio:
- Revisar los avances recientes en el tratamiento biológico de las enfermedades reumáticas autoinmunes.
- Centrarse específicamente en los avances en el tratamiento del lupus eritematoso sistémico.
- Para resaltar nuevos objetivos inmunológicos bajo investigación.
Principales métodos:
- Revisión de la literatura de los avances recientes.
- Centrarse en agentes biológicos y terapias dirigidas.
- Discusión de los tratamientos aprobados y la investigación en curso.
Principales resultados:
- Belimumab, un inhibidor de la supervivencia de las células B, es el primer tratamiento para el lupus eritematoso sistémico aprobado por la FDA en 50 años.
- Los tratamientos biológicos dirigidos han mejorado significativamente los resultados de los pacientes.
- Numerosos otros objetivos inmunológicos están actualmente bajo investigación.
Conclusiones:
- Los tratamientos biológicos representan un avance significativo en el manejo de enfermedades reumáticas autoinmunes.
- El tratamiento del lupus eritematoso sistémico ha experimentado grandes avances con nuevas terapias dirigidas.
- La investigación continua en objetivos inmunológicos promete nuevas innovaciones terapéuticas.
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