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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
La actividad del receptor μ-opioide constitutivo conduce a una analgesia endógena a largo plazo y a la dependencia
G Corder1, S Doolen, R R Donahue
1Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Science (New York, N.Y.)
|September 21, 2013
Resumen
La lesión tisular activa los receptores μ-opioides (MOR), proporcionando alivio del dolor a largo plazo. El bloqueo de esta actividad causa síntomas de abstinencia de opioides, lo que sugiere que las MOR previenen el desarrollo de dolor crónico.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Investigación del dolor Investigación del dolor.
- Farmacología Farmacología.
Sus antecedentes:
- Se sabe que los receptores opioides alivian el dolor agudo.
- Los mecanismos subyacentes a la inhibición opioide a largo plazo del dolor patológico no se comprenden completamente.
Objetivo del estudio:
- Investigar los mecanismos de la inhibición opiácea a largo plazo del dolor patológico.
- Explorar el papel de la actividad constitutiva del receptor μ-opioide (MOR) en la señalización del dolor y la dependencia de opiáceos.
Principales métodos:
- Inducción de lesiones tisulares en modelos animales.
- Bloqueo farmacológico de MOR (CA) utilizando agonistas inversos.
- Evaluación de la señalización nociceptiva espinal, la sensibilización al dolor y las características de abstinencia.
Principales resultados:
- La lesión tisular indujo MOR (CA) sostenida, reprimiendo la señalización nociceptiva espinal durante meses.
- El bloqueo de MOR (CA) restableció la sensibilización al dolor y precipitó los síntomas de abstinencia de opiáceos.
- Los síntomas de abstinencia involucraron la activación del receptor N-metil-D-aspartato de la adenilil ciclasa tipo 1.
Conclusiones:
- MOR ((CA) media tanto en la señalización analgésica como en un proceso compensatorio de dependencia de opiáceos.
- Tonic MOR ((CA) puede prevenir la transición del dolor agudo al crónico al suprimir la hiperalgesia de abstinencia.
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