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La arquitectura del circuito inhibidor del hipotálamo lateral orquesta la alimentación de los niños
Joshua H Jennings1, Giorgio Rizzi, Alice M Stamatakis
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Science (New York, N.Y.)
|September 28, 2013
Resumen
Los circuitos neuronales en el cerebro.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Neurociencia del comportamiento neurológico.
- La neurobiología es la neurobiología.
Sus antecedentes:
- Los trastornos alimenticios contribuyen significativamente a la epidemia mundial de obesidad.
- Los circuitos neuronales disfuncionales están implicados en comportamientos de alimentación aberrantes.
- El hipotálamo lateral (LH) juega un papel clave en los comportamientos de alimentación motivados.
Objetivo del estudio:
- Para definir el neurocircuito funcional preciso que controla la actividad neuronal del hipotálamo lateral (LH) en la alimentación.
- Investigar el papel de la amígdala extendida en la regulación de las neuronas LH y la ingesta de alimentos.
Principales métodos:
- Grabaciones electrofisiológicas en el hipotálamo lateral.
- Trazado y manipulación de circuitos neurales in vivo.
- Análisis de las entradas sinápticas en las neuronas glutamatérgicas de LH.
Principales resultados:
- Se encontró que las entradas sinápticas inhibidoras de la amígdala extendida inervan preferentemente y suprimen la actividad de la neurona glutamatérgica LH.
- Esta supresión de las neuronas de LH por la amígdala extendida juega un papel crítico en el control de la ingesta de alimentos.
Conclusiones:
- La amígdala extendida ejerce un control inhibitorio sobre las neuronas glutamatérgicas del hipotálamo lateral (LH) para regular la alimentación.
- La desregulación dentro de esta red neuronal, que involucra a la amígdala extendida y la LH, puede conducir a una alimentación inadecuada y contribuir a la obesidad.
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