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Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

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Video Experimental Relacionado

Updated: May 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

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El mapeo de los epigenomas humanos.

Chloe M Rivera1, Bing Ren

  • 1Ludwig Institute for Cancer Research, Institute of Genomic Medicine, UCSD Moores Cancer Center, University of California School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653, USA; The Biomedical Sciences Graduate Program, Institute of Genomic Medicine, UCSD Moores Cancer Center, University of California School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653, USA.

Cell
|October 1, 2013
PubMed
Resumen
Este resumen es generado por máquina.

Los mapas del epigenoma revelan información específica de la célula, lo que ayuda a comprender la regulación y el desarrollo de los genes. Esta revisión cubre las herramientas de mapeo del epigenoma y sus aplicaciones en la metilación del ADN y el análisis de la estructura de la cromatina.

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Last Updated: May 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

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Published on: August 13, 2020

Área de la Ciencia:

  • Genómica y epigenómica.
  • Biología Molecular Biología Molecular
  • Biología celular Biología celular.

Sus antecedentes:

  • El epigenoma, distinto del genoma, contiene información crucial específica de la célula.
  • Los avances en tecnologías de alto rendimiento han permitido el mapeo extensivo del epigenoma humano.

Objetivo del estudio:

  • Para revisar el actual conjunto de herramientas de mapeo del epigenoma.
  • Discutir la utilidad de los mapas del epigenoma para comprender la regulación y el desarrollo de los genes.
  • Para resaltar los avances y desafíos en el campo de la epigenómica.

Principales métodos:

  • Centrarse en las técnicas de mapeo para la metilación del ADN.
  • Análisis de los estados de modificación de la cromatina.
  • Caracterización de las estructuras de la cromatina.

Principales resultados:

  • Los mapas del epigenoma son fundamentales para identificar las secuencias reguladoras de los genes humanos.
  • Estos mapas ayudan a delinear programas complejos de desarrollo.
  • Las herramientas actuales proporcionan información sobre las variaciones epigenéticas entre los tipos de células.

Conclusiones:

  • El mapeo del epigenoma es un campo de rápido avance con implicaciones significativas para la biología y la medicina.
  • Se necesita más investigación para superar los desafíos existentes y utilizar plenamente los datos epigenómicos.
  • Los mapas del epigenoma ofrecen un poderoso recurso para descifrar la identidad y función celular.