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Identificación genética de un circuito neuronal que suprime el apetito
Matthew E Carter1, Marta E Soden, Larry S Zweifel
11] Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA [2] Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA [3] Department of Biology, Williams College, Williamstown, Massachusetts 01267, USA.
Nature
|October 15, 2013
Resumen
Los investigadores identificaron un circuito neuronal que suprime el apetito cuando comer es desfavorable. Esta vía involucra neuronas específicas en el núcleo parabraquial que se proyectan a la amígdala central, ofreciendo objetivos terapéuticos potenciales para la regulación del apetito.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La regulación del apetito.
- Los circuitos del tronco encefálico
Sus antecedentes:
- La supresión del apetito es crucial en condiciones como la enfermedad o la exposición a toxinas.
- El núcleo parabraquial en el tronco cerebral está implicado en el control del apetito.
- Las neuronas específicas dentro del núcleo parabraquial que regulan la alimentación permanecen sin identificar.
Objetivo del estudio:
- Para identificar las neuronas específicas y las proyecciones aguas abajo en el núcleo parabraquial responsable de la supresión del apetito.
- Para aclarar el circuito neuronal que media la supresión del apetito cuando comer es desfavorable.
Principales métodos:
- Utilizó herramientas anatómicas, optogenéticas y farmacogenéticas genéticamente codificadas en ratones.
- Investigó el papel de las neuronas que expresan péptidos relacionados con el gen de la calcitonina.
- Proyecciones examinadas desde el núcleo parabraquial hasta el núcleo central de la amígdala.
Principales resultados:
- Identificó un circuito que involucra neuronas que expresan péptidos relacionados con el gen de la calcitonina en el núcleo parabraquial que se proyecta hacia la amígdala central.
- La activación de este circuito suprime el apetito.
- La inhibición de este circuito aumenta la ingesta de alimentos y evita la inanición en modelos específicos.
Conclusiones:
- Un nuevo circuito neuronal desde el núcleo parabraquial hasta la amígdala central media la supresión del apetito.
- Este circuito es crítico cuando comer es desfavorable.
- El circuito identificado presenta objetivos terapéuticos potenciales para los trastornos del apetito.
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