Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

6.4K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.4K
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

1.3K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.3K
Drug Therapy01:28

Drug Therapy

450
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
450
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

1.5K
1.5K
Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

1.3K
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
1.3K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Quantitative Relationship Between White Matter Hyperintensity Volume and Fazekas Score on Brain MRI.

Stroke·2026
Same author

Head Acceleration Event Exposure during Pre-Season Training in Elite Men's Rugby Union.

Sports medicine - open·2026
Same author

What are healthcare practitioners' perspectives and experiences of strength assessment and strength training practices in community pulmonary rehabilitation? A qualitative study from the UK.

BMJ open·2026
Same author

Metabolic state determines the brain and direct islet effects of liraglutide on enhanced insulin secretion.

Diabetologia·2026
Same author

The Dark Tetrad and academic dishonesty: a systematic review and narrative synthesis of personality predictors of cheating, plagiarism, and deception in education.

BMC psychology·2026
Same author

Serum proteomic atlas reveals distinct molecular signatures of lupus nephritis activity, chronicity, and treatment response.

bioRxiv : the preprint server for biology·2026

Video Experimental Relacionado

Updated: May 6, 2026

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

11.5K

Combinaciones atípicas y impacto científico.

Brian Uzzi1, Satyam Mukherjee, Michael Stringer

  • 1Kellogg School of Management, Northwestern University, 2001 Sheridan Road, Evanston, IL 60208, USA.

Science (New York, N.Y.)
|October 26, 2013
PubMed
Resumen

La investigación científica de alto impacto equilibra el conocimiento convencional con combinaciones novedosas, lo que hace que sea dos veces más probable que sea altamente citado. Los equipos son más efectivos que los autores individuales para integrar estos nuevos elementos en los dominios científicos establecidos.

Más Videos Relacionados

Diagonal Method to Measure Synergy Among Any Number of Drugs
12:08

Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

21.0K
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

11.8K

Videos de Experimentos Relacionados

Last Updated: May 6, 2026

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

11.5K
Diagonal Method to Measure Synergy Among Any Number of Drugs
12:08

Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

21.0K
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

11.8K

Área de la Ciencia:

  • Investigación científica interdisciplinaria y estudios de innovación.

Sus antecedentes:

  • La novedad es crucial para las ideas creativas, pero los nuevos conceptos a menudo se basan en el conocimiento existente.
  • El equilibrio entre el conocimiento convencional y atípico puede ser clave para la innovación científica y el impacto.

Objetivo del estudio:

  • Investigar la relación entre los tipos de combinación de conocimientos y el impacto científico en todos los campos.
  • Para determinar las características de los trabajos científicos altamente citados.

Principales métodos:

  • Análisis de 17,9 millones de artículos científicos de todas las disciplinas.
  • Evaluación cuantitativa de los patrones de combinación de conocimientos (convencional vs. inusual).

Principales resultados:

  • La ciencia de mayor impacto utiliza predominantemente combinaciones convencionales de trabajo previo, con una notable inclusión de combinaciones inusuales.
  • Los artículos que presentan este equilibrio de combinaciones convencionales e inusuales tenían el doble de probabilidades de ser altamente citados.
  • Los equipos tenían un 37,7% más de probabilidades que los autores individuales de incorporar combinaciones novedosas en dominios de conocimiento familiares.

Conclusiones:

  • Un patrón universal en la ciencia sugiere que la combinación de conocimiento familiar con nuevos conocimientos genera un alto impacto.
  • La investigación colaborativa, especialmente por equipos, mejora la integración de ideas innovadoras dentro de los marcos científicos establecidos.