Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Sharpless Epoxidation02:57

Sharpless Epoxidation

4.2K
The conversion of allylic alcohols into epoxides using the chiral catalyst was discovered by K. Barry Sharpless and is known as Sharpless epoxidation. The use of a chiral catalyst enables the formation of one enantiomer of the product in excess. This chiral catalyst is mainly a chiral complex of titanium tetraisopropoxide and tartrate ester (specific stereoisomer). The stereoisomer used in the chiral catalyst dictates the formation of the enantiomer of the product. In other words, the use of...
4.2K
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

5.5K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
5.5K
Prochirality02:05

Prochirality

4.0K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
4.0K
Chirality in Nature02:30

Chirality in Nature

13.8K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
13.8K
SN2 Reaction: Stereochemistry02:23

SN2 Reaction: Stereochemistry

9.9K
In an SN2 reaction, the nucleophilic attack on the substrate and departure of the leaving group occurs simultaneously through a transition state. As the nucleophile approaches the substrate from the back-side, the configuration of the substrate carbon changes from tetrahedral to trigonal bipyramidal and then back to tetrahedral, leading to an inversion in the configuration of the product.
If the substrate is an achiral molecule at the α-carbon, the inversion of configuration is not...
9.9K
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons00:58

¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons

3.7K
Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
3.7K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

The Dual Subsurface Hydrogen (2H') Mechanism for Ethylene Hydrogenation on Pd.

The journal of physical chemistry. C, Nanomaterials and interfaces·2025
Same author

Single-Atom Doping at the Molecule-Metal Interface: How Rh Affects Surface Explosion Kinetics.

The journal of physical chemistry letters·2025
Same author

Structure Sensitive Reaction Kinetics of Chiral Molecules on Intrinsically Chiral Surfaces.

The journal of physical chemistry. C, Nanomaterials and interfaces·2024
Same author

H<sub>2</sub>-D<sub>2</sub> Exchange Activity and Electronic Structure of Ag <sub></sub> Pd<sub>1-</sub> Alloy Catalysts Spanning Composition Space.

ACS catalysis·2024
Same author

Atomic-scale origin of the enantiospecific decomposition of tartaric acid on chiral copper surfaces.

Chemical communications (Cambridge, England)·2024
Same author

Surface Segregation Studies in Ternary Noble Metal Alloys: Comparing DFT and Machine Learning with Experimental Data.

Chemphyschem : a European journal of chemical physics and physical chemistry·2024

Video Experimental Relacionado

Updated: May 5, 2026

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

9.6K

Las explosiones superficiales quirales superantioselectivas son explosiones superantiselectivas.

Andrew J Gellman1, Ye Huang, Xu Feng

  • 1Department of Chemical Engineering, Carnegie Mellon University , 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.

Journal of the American Chemical Society
|November 23, 2013
PubMed
Resumen

Las superficies quirales amplifican pequeñas diferencias de energía en las moléculas, lo que lleva a tasas de descomposición superenantiospecíficas. Este descubrimiento ofrece nuevos conocimientos sobre los orígenes de la quiralidad molecular.

Más Videos Relacionados

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

6.6K
Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

9.9K

Videos de Experimentos Relacionados

Last Updated: May 5, 2026

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

9.6K
Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

6.6K
Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

9.9K

Área de la Ciencia:

  • Química de las superficies.
  • Ciencia de los materiales Ciencia de los materiales.
  • Los orígenes de la vida.

Sus antecedentes:

  • Los materiales inorgánicos quirales existían antes de la vida, influyendo potencialmente en la homociralidad biomolecular.
  • Las interacciones enantioselectivas en superficies quirales generalmente producen enantioselectividades modestas debido a pequeñas diferencias de energía.

Objetivo del estudio:

  • Investigar la superenantiospecificidad derivada de las reacciones superficiales autocatalíticas en superficies quirales inorgánicas.
  • Explorar el papel de la cinética no lineal en la amplificación de la enantioselectividad.

Principales métodos:

  • Estudió la descomposición del ácido R,R- y S,S-tartárico en superficies de cristal único de cobre (Cu) naturalmente quirales.
  • Utilizó un mecanismo de explosión superficial mediada por vacío con cinética no lineal.

Principales resultados:

  • Se observó superenantiospecificidad en las tasas de descomposición de los enantiómeros del ácido tartárico en superficies quirales de Cu.
  • Las tasas de descomposición diferían hasta en dos órdenes de magnitud, a pesar de que las constantes de velocidad intrínsecas eran similares.

Conclusiones:

  • Las explosiones superficiales autocatalíticas pueden amplificar las sutiles diferencias de energía enantioselectiva, lo que lleva a una alta superenantiospecificidad.
  • Este mecanismo proporciona una vía potencial para comprender la amplificación de la quiralidad en las primeras condiciones de la Tierra.