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Obstrucción del flujo de aire, función pulmonar e incidencia de fibrilación auricular: el estudio de riesgo de

Jingjing Li¹, Sunil K Agarwal, Alvaro Alonso

¹University of North Carolina, Chapel Hill, NC (J.L., L.R.L., A.M.M., C.P., G.H.); Johns Hopkins University, Baltimore, MD (S.K.A.); University of Minnesota, Minneapolis (A.A.); New York University Medical Center, New York (S.B.); Mayo Clinic, Rochester, MN (A.M.C.); National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC (S.J.L.); and Wake Forest University, Winston Salem, NC (E.Z.S.).

|December 18, 2013

Resumen

La reducción de la función pulmonar, específicamente el menor volumen expiratorio forzado en 1 segundo (FEV1), aumenta el riesgo de fibrilación auricular (FA) en todos los grupos. Esta asociación es válida incluso para los que nunca han fumado y los individuos negros.

Área de la Ciencia:

Cardiología Cardiología.
Pulmonología Pulmonología.
Epidemiología La epidemiología.

Sus antecedentes:

La reducción del volumen expiratorio forzado en 1 segundo (FEV1) está relacionada con un mayor riesgo de fibrilación auricular (FA).
La investigación existente carece de datos específicos para los que nunca han fumado y las poblaciones negras con respecto a esta asociación.

Objetivo del estudio:

Investigar la relación entre el FEV1 y la FA incidente en una población diversa.
Proporcionar estimaciones específicas por raza y sexo del riesgo de FA asociado con la reducción del FEV1.

Principales métodos:

Análisis de 15.004 participantes negros y blancos del estudio de riesgo de aterosclerosis en las comunidades (ARIC).
Datos de espirometría recolectados al inicio del estudio; incidencia de FA rastreada durante 17,5 años a través de registros médicos y ECGs.
Ajuste multivariable para factores de riesgo cardiovascular y altura.

Principales resultados:

Se encontró una asociación inversa significativa entre el FEV1 y la FA incidente en todos los grupos de raza y sexo.
El cuartil más bajo de FEV1 se asoció con un riesgo significativamente mayor de FA: las HR oscilaron entre 1,37 y 2,36.
La obstrucción moderada / severa del flujo de aire también se correlacionó con un aumento de la incidencia de AF.

Conclusiones:

La reducción del FEV1 es un factor de riesgo independiente para una mayor incidencia de fibrilación auricular.
La enfermedad respiratoria obstructiva se asocia con un mayor riesgo de FA en una cohorte grande basada en la población.
Los hallazgos destacan la importancia de la salud respiratoria en la prevención de enfermedades cardiovasculares.

Palabras clave:

La fibrilación auricular es una fibrilación auricular.El volumen de exhalación forzada.enfermedad pulmonar, enfermedad obstructiva crónica.fenómenos fisiológicos de las vías respiratorias.factores de riesgo de los factores de riesgo.capacidad vital de la capacidad vital.

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