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La captura y liberación mediada por pH de moléculas cargadas con nanocápsulas huecas porosas y porosas
Sergey A Dergunov1, Jeffrey Durbin, Sambit Pattanaik
1Department of Chemistry, Saint Louis University , 3501 Laclede Avenue, St. Louis, Missouri 63103, United States.
Journal of the American Chemical Society
|December 27, 2013
Resumen
La carga de los nanoporos en las nanocápsulas controla el transporte de moléculas cargadas. El ajuste del pH permite el atrapamiento de moléculas y desencadena la liberación de estas nanocápsulas.
Área de la Ciencia:
- Ciencia de los materiales Ciencia de los materiales.
- Nanotecnología La nanotecnología es la nanotecnología.
- Química Física es la química física.
Sus antecedentes:
- Las nanocápsulas porosas huecas ofrecen potencial para el transporte molecular controlado.
- La regulación del movimiento de moléculas cargadas a través de nanoestructuras es un desafío clave en la nanotecnología.
Objetivo del estudio:
- Investigar el papel de la carga de nanoporo en el control del transporte molecular a través de las nanocápsulas.
- Para demostrar el atrapamiento mediado por pH y la liberación de moléculas cargadas utilizando estas nanocápsulas.
Principales métodos:
- Fabricación de nanocápsulas porosas huecas con carga de superficie sintonizable.
- Utilizando las variaciones de pH en soluciones acuosas para manipular las interacciones moleculares con nanoporos.
- Caracterización del transporte molecular y la dinámica de encapsulación/liberación.
Principales resultados:
- Se demostró que la carga superficial de los nanoporos influye directamente en el transporte de moléculas cargadas.
- Mostró la capacidad de atrapar de manera reversible moléculas cargadas dentro de las nanocápsulas mediante la alteración del pH externo.
- Se desencadenó con éxito la liberación del contenido encapsulado a través de cambios de pH controlados.
Conclusiones:
- La carga de nanoporo es un factor crítico para regular el transporte de moléculas cargadas en las nanocápsulas.
- El control sensible al pH sobre el atrapamiento y la liberación molecular se puede lograr con estas nanocápsulas.
- Este trabajo proporciona una base para el desarrollo de sistemas avanzados de nanocarrier para la entrega y separación específicas.
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