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La pregnenolona puede proteger el cerebro de la intoxicación por cannabis
Monique Vallée1, Sergio Vitiello, Luigi Bellocchio
1INSERM, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France.
Science (New York, N.Y.)
|January 4, 2014
Resumen
La pregnenolona, un precursor de la hormona esteroide, reduce los efectos del THC al inhibir el receptor CB1. Este descubrimiento revela un mecanismo protector del cerebro contra la sobreactivación de los cannabinoides, ofreciendo tratamientos potenciales para la adicción al cannabis.
Área de la Ciencia:
- La neuroendocrinología en neuroendocrinología.
- La farmacología de los cannabinoides.
Sus antecedentes:
- La pregnenolona es el precursor de todas las hormonas esteroides.
- Sus funciones funcionales siguen siendo en gran medida inexploradas.
- El principal compuesto activo del cannabis sativa, el Δ(9)-tetrahidrocannabinol (THC), activa el receptor CB1 en el cerebro.
Objetivo del estudio:
- Para investigar los efectos funcionales de la pregnenolona.
- Para dilucidar la interacción entre la pregnenolona y la activación del receptor CB1 mediada por THC.
Principales métodos:
- La administración de THC para activar los receptores CB1.
- Medición de la síntesis de pregnenolona en el cerebro.
- Evaluación del efecto de la pregnenolona en las respuestas inducidas por el THC.
Principales resultados:
- La administración de THC aumenta significativamente la síntesis de pregnenolona en el cerebro.
- La pregnenolona actúa como un inhibidor específico del receptor CB1.
- La pregnenolona reduce varios efectos adversos asociados con la exposición al THC.
Conclusiones:
- Un nuevo bucle de retroalimentación negativa que involucra a los receptores de pregnenolona y CB1 protege el cerebro de la sobreactivación.
- Este mecanismo ofrece una potencial estrategia terapéutica para el manejo de la intoxicación y adicción al cannabis.
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