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Raquitismo y raquitismo
Charlotte Jane Elder1, Nicholas J Bishop1
1University of Sheffield, Academic Unit of Child Health, Sheffield Children's Hospital, Western Bank, Sheffield, UK.
Lancet (London, England)
|January 14, 2014
Resumen
El raquitismo, una enfermedad ósea global, es causada principalmente por la insuficiencia de vitamina D que conduce a bajos niveles de fosfato. Las directrices actuales de vitamina D para bebés no son claras y necesitan revisión para prevenir esta condición.
Área de la Ciencia:
- La pediatría es la medicina de los niños.
- Ciencias de la Nutrición Ciencias de la Nutrición
- Endocrinología Endocrinología.
Sus antecedentes:
- El raquitismo, conocido históricamente como "la enfermedad inglesa", sigue siendo un problema de salud mundial frecuente.
- La causa principal es la insuficiencia de vitamina D, lo que lleva a la deficiencia de fosfato en las placas de crecimiento y las superficies óseas.
- Los trastornos hereditarios que afectan el metabolismo de los fosfatos resaltan la complejidad de la homeostasis mineral.
Objetivo del estudio:
- Para abordar las inconsistencias y la falta de claridad en las directrices actuales de suplementación de vitamina D para bebés.
- Hacer hincapié en la necesidad de revisar las recomendaciones para combatir eficazmente la incidencia generalizada de raquitismo.
Principales métodos:
- Revisión de la literatura existente sobre la etiología del raquitismo y el metabolismo de la vitamina D.
- Análisis de las actuales directrices mundiales de alimentación infantil y suplementación de vitamina D.
- Evaluación del impacto de la disponibilidad de fosfato en la mineralización ósea.
Principales resultados:
- El suministro inadecuado de vitamina D es el principal impulsor del raquitismo en todo el mundo.
- La guía existente de vitamina D para bebés es fragmentada, contradictoria e insuficiente para la erradicación de enfermedades.
- Comprender el metabolismo de los fosfatos es crucial para abordar la patogénesis del raquitismo.
Conclusiones:
- Las recomendaciones actuales de vitamina D para los bebés requieren una aclaración y revisión significativas.
- Un enfoque unificado y basado en la evidencia para la provisión de vitamina D es necesario para erradicar el raquitismo.
- Se necesita más investigación sobre el papel del fosfato en la salud ósea.
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