La activación prematura del complejo SLX4 por Vpr promueve la detención de G2/M y el escape de la detección inmune

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Updated: May 3, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

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Nadine Laguette1, Christelle Brégnard1, Pauline Hue1

  • 1Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000, France.

Cell
|January 14, 2014
PubMed
Resumen

La proteína Vpr del VIH causa la detención del ciclo celular mediante la activación del complejo SLX4, que implica la escisión del ADN e inhibe las respuestas antivirales. Este estudio identifica los factores celulares clave en el Vpr.

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