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Fotofarmacología: más allá de la prueba de principio
Willem A Velema1, Wiktor Szymanski, Ben L Feringa
1Center for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Journal of the American Chemical Society
|January 25, 2014
Resumen
La fotofarmacología utiliza la luz para controlar la actividad de los fármacos con precisión en el tiempo y el espacio. Este enfoque supera la mala selectividad de los fármacos, reduciendo los efectos secundarios y la resistencia a terapias más seguras y efectivas.
Área de la Ciencia:
- Química Medicinal La Química Medicinal es un campo de estudio de la química medicinal.
- Farmacología Farmacología.
- Biotecnología La biotecnología es la biotecnología.
Sus antecedentes:
- La escasa selectividad de los fármacos causa desafíos significativos en la farmacoterapia, lo que lleva a efectos secundarios, toxicidad ambiental y resistencia a los medicamentos.
- Las limitaciones actuales en el control de la actividad de la droga en el tiempo y el espacio obstaculizan la eficacia terapéutica y la seguridad.
Objetivo del estudio:
- Proporcionar una visión general del campo emergente de la fotofarmacología.
- Discutir los principios, desafíos y potencial terapéutico futuro del uso de la luz para controlar la acción de los fármacos.
Principales métodos:
- Incorporación de grupos fotointercambiables en moléculas bioactivas.
- Utilizando la luz como un estímulo externo para un preciso control espacio-temporal de la actividad farmacológica.
Principales resultados:
- La fotofarmacología ofrece una nueva estrategia para mejorar la selectividad de los fármacos.
- El control mediado por luz permite una alta precisión espacio-temporal en la administración y activación del fármaco.
Conclusiones:
- La fotofarmacología presenta una solución prometedora para superar las limitaciones de la farmacoterapia convencional.
- La investigación adicional en diseño molecular y aplicaciones terapéuticas es esencial para realizar todo el potencial de este campo.
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