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Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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Video Experimental Relacionado

Updated: May 3, 2026

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples
09:51

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples

Published on: April 10, 2026

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Aceleración hasta la pluripotencia.

Josh G Chenoweth1, Ronald D McKay1

  • 1Lieber Institute for Brain Development, 855 N. Wolfe Street, Baltimore, MD 21205 USA.

Cell
|February 18, 2014
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores descubrieron un nuevo tipo de célula que exhibe un ciclo celular ultrarrápido. Esta célula es esta célula.

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Área de la Ciencia:

  • Biología celular Biología celular.
  • Biología del desarrollo Biología del desarrollo.
  • La epigenética es la epigenética.

Sus antecedentes:

  • La reprogramación celular no estocástica sin manipulación genética sigue siendo un desafío significativo.
  • La comprensión de los mecanismos de determinación rápida y sincrónica del destino celular es crucial.

Objetivo del estudio:

  • Identificar y caracterizar un tipo de célula capaz de una rápida reprogramación no genética.
  • Para investigar las propiedades de las células con un ciclo celular ultrarrápido.

Principales métodos:

  • Análisis del ciclo celular Análisis del ciclo celular
  • Imágenes de imagen de alta resolución.
  • El análisis de la progenie.

Principales resultados:

  • Identificación de una célula definida por un ciclo celular ultrarrápido.
  • Demostración de que la progenie de esta célula se reprograma de manera sincrónica y rápida.
  • Caracterización de la dinámica única del ciclo celular.

Conclusiones:

  • Se ha identificado un nuevo tipo de célula con propiedades únicas de reprogramación.
  • El ciclo celular ultrarrápido es clave para la reprogramación sincrónica y rápida observada.
  • Este hallazgo abre nuevas vías para comprender la determinación del destino celular.