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Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
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Tratamiento de la tromboflebitis superficial de las extremidades inferiores
Marcello Di Nisio1, Saskia Middeldorp2
1Department of Medical, Oral, and Biotechnological Sciences, Università "G. D'Annunzio" of Chieti-Pescara, Chieti, Italy2Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
JAMA
|February 20, 2014
Resumen
Fondaparinux reduce eficazmente los eventos tromboembólicos venosos sintomáticos (ETV) y la extensión de la trombosis venosa superficial en pacientes con tromboflebitis superficial de las extremidades inferiores. Otros tratamientos como la heparina de bajo peso molecular también son prometedores para prevenir la extensión y la recurrencia.
Área de la Ciencia:
- La medicina vascular es una medicina vascular.
- Investigación de la trombosis.
- Farmacología Farmacología.
Sus antecedentes:
- La tromboflebitis superficial de las extremidades inferiores es una condición común.
- La identificación de tratamientos que minimicen las complicaciones como los eventos tromboembólicos venosos (ETV) y la extensión es crucial.
Objetivo del estudio:
- Evaluar los tratamientos para la tromboflebitis superficial de las extremidades inferiores.
- Para determinar las asociaciones con tasas más bajas de TEV, sangrado mayor y trombosis venosa superficial de extensión.
Principales métodos:
- Revisión sistemática y metanálisis de ensayos controlados aleatorios.
- Comparación de varios anticoagulantes y agentes antiinflamatorios frente al placebo.
Principales resultados:
- Fondaparinux (2,5 mg diarios durante 45 días) redujo significativamente las ETV sintomáticas, la extensión de la trombosis venosa superficial y la recurrencia sin aumentar el sangrado mayor en comparación con el placebo.
- La heparina de bajo peso molecular y los antiinflamatorios no esteroideos se asociaron con una reducción de la extensión / recurrencia, pero los datos de TEV no fueron concluyentes.
Conclusiones:
- Fondaparinux es un tratamiento prometedor para la tromboflebitis superficial de las extremidades inferiores, que ofrece beneficios en la prevención de TEV y la extensión local.
- Se necesitan más investigaciones para aclarar el papel de LMWH y AINE en la prevención de ETV en esta condición.
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