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La formación de brotes en las extremidades de los vertebrados se inicia por la transición localizada del epitelio al
Jerome Gros1, Clifford J Tabin
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Science (New York, N.Y.)
|March 15, 2014
Resumen
Los brotes de las extremidades de los vertebrados se inician antes de lo que se creía. Los progenitores de las extremidades mesenquimales surgen de la transición localizada de epitelio a mesenquima (EMT), regulada por los genes Tbx5 y Fgf10.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología celular y molecular Biología celular y molecular.
Sus antecedentes:
- El desarrollo de las extremidades de los vertebrados comienza con pequeños brotes.
- Se conocen los mecanismos moleculares de la iniciación de las extremidades, pero los eventos celulares no están claros.
Objetivo del estudio:
- Esclarecer los orígenes celulares de los progenitores de las extremidades mesenquimales durante el desarrollo temprano de las extremidades.
Principales métodos:
- Investigó el papel de la transición epitelial a mesenquimal (EMT) en la formación de brotes de las extremidades.
- Se analizó la regulación de la EMT por genes específicos (Tbx5, Fgf10).
Principales resultados:
- Los progenitores de las extremidades mesenquimales se originan en la EMT localizada del epitelio coelómico.
- Este EMT ocurre dentro de campos de extremidades presuntas y está regulado por Tbx5 y Fgf10.
- Los brotes de las extremidades se inician antes de lo que se pensaba debido a la EMT, no a la proliferación diferencial.
Conclusiones:
- La iniciación del capullo de la extremidad está impulsada por la transición localizada del epitelio al mesenquima.
- Tbx5 y Fgf10 juegan un papel clave en la regulación de este proceso crucial del desarrollo.
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