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Dirigiendo la regioselectividad controlada por grupo en una oxigenación enzimática de enlace C-H

Solymar Negretti1, Alison R H Narayan, Karoline C Chiou

  • 1Department of Medicinal Chemistry, §Life Sciences Institute, ⊥Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|March 18, 2014
PubMed
Resumen

La regioselectividad de la hidroxilación enzimática puede ser modulada por la ingeniería del sustrato. El reemplazo de los grupos de anclaje naturales por grupos sintéticos altera la monooxigenasa P450 PikCD50N-RhFRED.

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