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Intercambio multimodal de conformación y solubilidad en polipéptidos derivados de homocisteína

Jessica R Kramer¹, Timothy J Deming

¹Department of Chemistry and Biochemistry and ‡Department of Bioengineering, University of California , Los Angeles, California 90095, United States.

Journal of the American Chemical Society

|April 4, 2014

Resumen

Los investigadores desarrollaron nuevos polímeros multirresponsivos a partir de poli (S-alquilo-L-homocisteína) Estos polímeros cambian de conformación o solubilidad en respuesta a diferentes estímulos de manera reversible y bajo condiciones suaves.

Área de la Ciencia:

Química de Polímeros La Química de Polímeros es la química de los polímeros.
Ciencia de los materiales Ciencia de los materiales.
Biotecnología La biotecnología es la biotecnología.

Sus antecedentes:

El desarrollo de polímeros avanzados con propiedades sintonizables es crucial para nuevas aplicaciones.
Los polímeros sensibles a estímulos ofrecen un control dinámico sobre las características del material.

Objetivo del estudio:

Diseñar y sintetizar una nueva clase de polímeros multirresponsivos.
Investigar su capacidad única para responder de manera diferente a diversos estímulos.

Principales métodos:

Síntesis de poli (S-alquilo-L-homocisteína) y sus derivados.
Caracterización de las propiedades del polímero y capacidad de respuesta.
Evaluación de los cambios inducidos por estímulos en la conformación de la cadena y la solubilidad en agua.

Principales resultados:

Ha sintetizado con éxito poli (S-alquilo-L-homocisteína), una nueva clase de polímeros.
Comportamiento multirresponsivo demostrado, con diferentes estímulos que inducen cambios distintos.
Cambios reversibles observados en la conformación de la cadena y la solubilidad en agua bajo condiciones suaves.
Incorporación de grupos solubles en agua y enlaces tioéteres multirresponsivos.

Conclusiones:

Las poli ((S-alquilo-L-homocisteína) se preparan fácilmente, son polímeros multirresponsivos con perfiles de estímulo-respuesta únicos.
Estos polímeros exhiben una conmutación multimodal reversible de propiedades.
El sistema es prometedor para aplicaciones que requieren respuestas acopladas a múltiples entradas externas.

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