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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
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In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
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Las proteínas de feromonas murinas constituyen un código combinatorio dependiente del contexto que rige múltiples

Angeldeep W Kaur1, Tobias Ackels2, Tsung-Han Kuo1

  • 1Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.

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|April 29, 2014
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Resumen

Los ratones usan un código combinatorio de las principales proteínas urinarias (MUP) para distinguirse de los demás, aprendiendo su firma de olor única. Esta comunicación química también desencadena la agresión, mostrando que los MUP transmiten información social tanto aprendida como innata.

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Área de la Ciencia:

  • Comportamiento animal Comportamiento animal.
  • Neuroetología La neuroetología.
  • Ecología química y ecología química.

Sus antecedentes:

  • Las interacciones sociales se basan en la interpretación de señales.
  • Los ratones utilizan la auto-discriminación u otra discriminación para el contramarcado territorial.
  • Las señales olfativas son críticas para el reconocimiento social.

Objetivo del estudio:

  • Identificar señales químicas para la discriminación social en ratones.
  • Comprender cómo se interpretan estas señales.
  • Investigar el papel de las principales proteínas urinarias (MUP) en el comportamiento.

Principales métodos:

  • Desarrolló un ensayo de contra-marcado olfativo dependiente del olfato.
  • Se probó el efecto de las principales proteínas urinarias (MUP) en el comportamiento del ratón.
  • Estrategias de detección sensorial analizadas para los MUP.

Principales resultados:

  • Las proteínas urinarias principales (MUP) son suficientes para provocar el contra-marcado.
  • Los MUP se detectan a través de una estrategia combinatoria, no de neuronas individuales.
  • Se desarrolla una firma quimiosensorial "auto" aprendida a través de la exposición a MUP.
  • Los MUP pueden desencadenar la agresión independientemente de la experiencia, pero dependiendo del contexto.

Conclusiones:

  • Las señales químicas emitidas individualmente se interpretan a través de permutaciones y relaciones combinatorias.
  • Los MUP transmiten información tanto fija (agresión) como aprendida (auto-reconocimiento).
  • Este sistema de comunicación química apoya diversos comportamientos sociales.