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Amplificación y transducción de señales en fotosensores fitocromos
Heikki Takala1,2, Alexander Björling2, Oskar Berntsson2
1Nanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, 40014 Jyväskylä, Finland.
Nature
|April 30, 2014
Resumen
Los bacteriofitocromos utilizan un conservado
Área de la Ciencia:
- La bioquímica es la bioquímica.
- Biología Estructural Biología estructural.
- Microbiología Microbiología.
Sus antecedentes:
- Los fitocromos son proteínas esenciales sensibles a la luz roja en bacterias, plantas y hongos.
- Los fitocromos bacterianos poseen dominios fotosensoriales y reguladores cruciales para las funciones celulares.
- La comprensión del relé de señales en los fitocromos requiere elucidar el estado de señalización activado.
Objetivo del estudio:
- Para determinar las estructuras cristalinas y de solución de los estados de reposo y activado de un núcleo fotosensorial de bacteriofitocromo.
- Para dilucidar el mecanismo de transmisión de señales desde el cromóforo al dominio regulador en los bacteriofitocromos.
Principales métodos:
- Cristalografía de rayos X con rayos X.
- Determinación de la estructura de la solución determinación de la estructura de la solución
- Análisis estructural comparativo de los estados de reposo y activado.
Principales resultados:
- Se revelaron distintas formas diméricas abiertas (activadas) y cerradas (en reposo) del núcleo fotosensorial del bacteriofitocromo.
- Se identificó un elemento "lengua" conservado que se pliega de nuevo para mediar reordenamientos a escala nanométrica.
- Amplificación de la señal demostrada de los cambios de cromóforos a escala atómica a ångstrom y cambios de conformación a escala nanométrica.
Conclusiones:
- El estudio descubre un inusual mecanismo de retransmisión de señales en los bacteriofitocromos.
- Los cambios de conformación se amplifican a través de un elemento de "lengua" plegable.
- Proporciona un plan estructural para la comprensión de las redes de señalización fitocromáticas.
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