Jove
Visualize
Contáctanos

Videos de Conceptos Relacionados

Tight Junctions01:29

Tight Junctions

6.8K
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
6.8K
Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

19.1K
The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight...
19.1K
Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

30.6K
30.6K
Anchoring Junctions01:03

Anchoring Junctions

4.3K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
4.3K
Adherens Junctions01:24

Adherens Junctions

5.8K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
5.8K
Classification of Epithelial Tissues: Simple Epithelium01:30

Classification of Epithelial Tissues: Simple Epithelium

12.5K
Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
12.5K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

ZONAB Regulates DNA Methylation, Mitochondrial Function, and Entry into Cell Senescence of Endothelial Cells.

Cells·2026
Same author

ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network.

Cells·2024
Same author

Correction: The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice.

PloS one·2023
Same author

Tight junctions.

Current biology : CB·2023
Same author

ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions.

Cells·2022
Same author

Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis.

The Journal of cell biology·2022
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Ver todos los artículos relacionados
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Video Experimental Relacionado

Updated: Apr 30, 2026

Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique
06:43

Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique

Published on: May 26, 2021

5.4K

SnapShot: Las uniones estrechas epiteliales.

Karl Matter1, Maria S Balda1

  • 1Department of Cell Biology, Institute of Ophthalmology, University College London, EC1V 9EL London, UK.

Cell
|May 13, 2014
PubMed
Resumen
Este resumen es generado por máquina.

Las uniones estrechas crean una barrera entre las superficies celulares, controlando lo que pasa a través de ellas. Son cruciales para la polaridad celular y la señalización, influyendo en el comportamiento celular y la expresión génica.

Más Videos Relacionados

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

11.2K
Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
11:49

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Published on: June 12, 2014

18.2K

Videos de Experimentos Relacionados

Last Updated: Apr 30, 2026

Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique
06:43

Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique

Published on: May 26, 2021

5.4K
Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

11.2K
Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
11:49

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Published on: June 12, 2014

18.2K

Área de la Ciencia:

  • Biología celular Biología celular.
  • Biología epitelial Biología epitelial.
  • Biología Molecular Biología Molecular

Sus antecedentes:

  • Las uniones estrechas establecen dominios de superficie celular apical y basolateral distintos.
  • Funcionan como una barrera de difusión paracelular, separando compartimentos de diferente composición.
  • Las uniones estrechas son vitales para mantener la polaridad de las células epiteliales y regular las vías de señalización.

Objetivo del estudio:

  • Para ilustrar los componentes de las uniones cerradas.
  • Para describir la organización de las uniones estrechas.
  • Para explicar las diversas funciones de las uniones estrechas en las células epiteliales.

Principales métodos:

  • Revisión de la literatura existente y la investigación sobre la estructura y la función de las uniones estrechas.
  • Análisis de los datos morfológicos y funcionales relacionados con las uniones estrechas.
  • Síntesis de información sobre los mecanismos de señalización regulados por uniones estrechas.

Principales resultados:

  • Las uniones estrechas son estructuras complejas de proteínas que forman un sello entre las células epiteliales.
  • Regulan eficazmente el paso de las moléculas a través del espacio paracelular.
  • Estas uniones juegan un papel clave en la determinación de la forma celular y la modulación de la expresión génica.

Conclusiones:

  • Las uniones estrechas son esenciales para la función de la barrera epitelial y la polaridad celular.
  • Sus componentes y organización son fundamentales para regular los procesos celulares.
  • Comprender la función de las uniones estrechas proporciona información sobre la biología epitelial y las enfermedades.