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Los intercambios sistemáticos de dominio de las sintetasas iterativas no reductoras de policetido proporcionan una

Adam G Newman1, Anna L Vagstad, Philip A Storm

  • 1Department of Chemistry, The Johns Hopkins University , 3400 N. Charles Street, Baltimore, Maryland 21218, United States.

Journal of the American Chemical Society
|May 13, 2014
PubMed
Resumen

La ingeniería iterativa, sin reducción de las poliquetidas sintasas (NR-PKSs) es clave para la producción de nuevos metabolitos. El intercambio de dominio exitoso requiere una interacción de dominio eficiente y tasas de catálisis que excedan el descarrilamiento espontáneo.

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