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Los cambios de flujo compensatorio dentro de una red de tráfico endocítico mantienen la robustez térmica de la
Hideyuki Shimizu1, Simon A Woodcock1, Marian B Wilkin1
1University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
Cell
|May 27, 2014
Resumen
La señalización del desarrollo, como Notch, permanece funcional a través de las temperaturas. Esta robustez se logra a través de rutas de tráfico endocítrico adaptables que regulan las vías de señalización, asegurando el desarrollo normal en condiciones térmicas variables.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- La señalización celular de las células.
- Mecanismos moleculares de la robustez térmica
Sus antecedentes:
- Las vías de señalización del desarrollo exhiben una notable resistencia a los cambios ambientales, particularmente a las fluctuaciones de temperatura.
- En organismos ectotérmicos como Drosophila, la señalización Notch mantiene la funcionalidad a través de un amplio espectro de temperatura.
Objetivo del estudio:
- Para dilucidar los mecanismos subyacentes a la compensación de temperatura en la señalización Notch.
- Investigar el papel de las vías endocíticas en el mantenimiento de la robustez de la señal del desarrollo.
Principales métodos:
- Combinación de enfoques experimentales y computacionales.
- Análisis de las rutas de activación de Notch dependientes de los endocitos.
- Investigación de la ubiquitinación dependiente de la temperatura de Notch.
Principales resultados:
- La compensación de la temperatura de la señalización de Notch está mediada por un conjunto diverso de rutas endocíticas.
- Un equilibrio alterado de los flujos de tráfico y la ubiquitinación dependiente de la temperatura contribuyen a la compensación térmica.
- Las vías de tráfico flexibles soportan la señalización Notch a bajas temperaturas y la restringen a altas temperaturas.
Conclusiones:
- Un conjunto flexible de rutas de tráfico endocítico actúa como un módulo de robustez para la señalización Notch.
- Estos mecanismos amplían el rango fisiológico para el desarrollo normal bajo temperaturas variables.
- Estrategias similares de robustez térmica pueden aplicarse a otras señales de desarrollo.
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