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Updated: Apr 27, 2026

PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase
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PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase

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Mecanismo concertado versus paso a paso en la timidilato sintasa

Zahidul Islam1, Timothy S Strutzenberg, Ilya Gurevic

  • 1Department of Chemistry, The University of Iowa , Iowa City, Iowa 52242-1727, United States.

Journal of the American Chemical Society
|June 21, 2014
PubMed
Resumen

Este estudio investiga el mecanismo de reacción de la timidilato sintasa (TSase). Los hallazgos apoyan un mecanismo concertado para la transferencia de hidruro, destacando el papel de la arginina en el sitio activo en la catálisis.

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