Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

17.3K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
17.3K
Protein Complex Assembly02:41

Protein Complex Assembly

12.5K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
12.5K
Protein Complex Assembly02:41

Protein Complex Assembly

1.6K
1.6K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

4.7K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
4.7K
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.1K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.1K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

16.6K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
16.6K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning.

Nature neuroscience·2025
Same author

Learning produces an orthogonalized state machine in the hippocampus.

Nature·2025
Same author

Organizing memories for generalization in complementary learning systems.

Nature neuroscience·2023
Same author

Hippocampal and thalamic afferents form distinct synaptic microcircuits in the mouse infralimbic frontal cortex.

Cell reports·2021
Same author

Rapid synaptic plasticity contributes to a learned conjunctive code of position and choice-related information in the hippocampus.

Neuron·2021
Same author

Bursting potentiates the neuro-AI connection.

Nature neuroscience·2021
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
Same journal

Structural basis for host membrane binding and remodeling by invading malaria parasites.

Cell·2026
Same journal

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning.

Cell·2026
Same journal

Arc mediates intercellular tau transmission via extracellular vesicles.

Cell·2026
Same journal

Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression.

Cell·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Apr 27, 2026

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
07:09

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

6.8K

Conjuntos de células de ensamblaje.

Nelson Spruston1

  • 1Howard Hughes Medical Institute, Janelia Farm Research Campus 19700 Helix Drive, Ashburn, Virginia 20147, USA.

Cell
|June 21, 2014
PubMed
Resumen
Este resumen es generado por máquina.

Las vías de desarrollo neuronal recién descubiertas revelan cómo las neuronas precursoras migran para formar conjuntos celulares funcionales en el hipocampo. Esta investigación arroja luz sobre las bases del desarrollo de la codificación de la memoria y la formación de circuitos neuronales.

Más Videos Relacionados

Author Spotlight: Development of a Scaffold-Free Acoustic Assembly Method for High-Quality 3D Cell Spheroid Culture
05:17

Author Spotlight: Development of a Scaffold-Free Acoustic Assembly Method for High-Quality 3D Cell Spheroid Culture

Published on: October 13, 2023

1.8K
Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

4.6K

Videos de Experimentos Relacionados

Last Updated: Apr 27, 2026

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
07:09

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

6.8K
Author Spotlight: Development of a Scaffold-Free Acoustic Assembly Method for High-Quality 3D Cell Spheroid Culture
05:17

Author Spotlight: Development of a Scaffold-Free Acoustic Assembly Method for High-Quality 3D Cell Spheroid Culture

Published on: October 13, 2023

1.8K
Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

4.6K

Área de la Ciencia:

  • La neurociencia es la neurociencia.
  • Biología del desarrollo Biología del desarrollo.
  • Biología celular Biología celular.

Sus antecedentes:

  • El hipocampo es crucial para la formación de la memoria, utilizando "ensamblajes celulares" para la codificación de la información.
  • El cableado del circuito neuronal durante el desarrollo es un factor clave en la función del hipocampo.
  • Comprender la migración neuronal es esencial para comprender el desarrollo y la función del cerebro.

Objetivo del estudio:

  • Para aclarar los patrones de migración de las neuronas que se originan a partir de un solo precursor.
  • Para investigar cómo estas neuronas establecen conjuntos funcionalmente sincrónicos dentro del hipocampo.
  • Proporcionar nuevos conocimientos sobre los mecanismos de desarrollo subyacentes a la formación del circuito del hipocampo.

Principales métodos:

  • Rastrear la migración de neuronas individuales derivadas de precursores comunes.
  • Analizar la formación de conjuntos neuronales y su sincronía funcional.
  • Utilizando técnicas avanzadas de imagen y genéticas para estudiar el desarrollo neuronal.

Principales resultados:

  • Identificó vías y mecanismos específicos que rigen la migración de las neuronas derivadas de precursores.
  • Demostró cómo estas neuronas migratorias se reúnen en grupos funcionalmente conectados.
  • Mostró la formación de conjuntos sincrónicos críticos para el procesamiento de la información del hipocampo.

Conclusiones:

  • La migración neuronal de precursores comunes es un determinante crítico de la organización del circuito del hipocampo.
  • El estudio proporciona una nueva comprensión de cómo el desarrollo de circuitos del hipocampo forman ensamblajes celulares funcionales.
  • Estos hallazgos tienen implicaciones para la comprensión de la codificación de la memoria y los trastornos neurológicos relacionados con la disfunción del circuito.