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γ-Secretasa: una estructura en forma de herradura trae buena suerte

Michael S Wolfe1, Dennis J Selkoe1

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Cell
|July 19, 2014
PubMed
Resumen

La estructura de la proteasa gamma-secretasa (γ-secretasa) intramembrana revela una forma de herradura, lo que ayuda al reconocimiento del sustrato. Este avance avanza la comprensión de su papel en la señalización celular y la investigación de la enfermedad de Alzheimer.

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