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¿Son los ensayos clínicos una inversión rentable?
1Department of Health Administration, University of Toronto, Ontario, Canada.
JAMA
|October 6, 1989
Resumen
Los ensayos clínicos, incluso los costosos, ofrecen un fuerte valor económico. Esta investigación demuestra que invertir en ensayos aleatorizados es rentable, lo que produce beneficios significativos para la salud de las poblaciones.
Área de la Ciencia:
- Economía de la salud Economía de la salud
- Metodología de la investigación clínica Metodología de la investigación clínica.
- Análisis de la inversión biomédica Análisis de la inversión biomédica
Sus antecedentes:
- La evaluación de la viabilidad económica de la investigación clínica es crucial para la asignación de fondos.
- Las evaluaciones anteriores a menudo se centraron en las intervenciones en lugar de en los ensayos en sí.
- Comprender el retorno de la inversión para los ensayos clínicos informa las futuras prioridades de investigación.
Objetivo del estudio:
- Evaluar el atractivo económico de llevar a cabo ensayos clínicos aleatorizados.
- Para cuantificar la rentabilidad de los ensayos aleatorizados seleccionados.
- Proporcionar datos para los responsables políticos con respecto a la financiación de la investigación biomédica.
Principales métodos:
- Se desarrolló un modelo de costo-efectividad para evaluar siete ensayos aleatorizados seleccionados.
- El modelo incorporó los costos del desempeño del ensayo y los beneficios proyectados del estado de salud.
- Los coeficientes incrementales de costo-efectividad (ICER) se calcularon por año de vida ahorrado.
Principales resultados:
- Los ICER para los ensayos estudiados oscilaron entre $ 2- $ 3 por año de vida ahorrado (aspirina para angina inestable) a $ 396- $ 685 por año de vida ahorrado (estudio de cirugía de arteria coronaria).
- Estos ratios de costo-efectividad fueron significativamente más favorables que los de las intervenciones con eficacia probada.
- Los hallazgos indican que los ensayos clínicos evaluados representaron una inversión económica sólida.
Conclusiones:
- Los ensayos clínicos seleccionados, incluidos algunos controvertidos y costosos, son inversiones económicamente atractivas.
- La rentabilidad de la investigación clínica apoya su valor para mejorar la salud de la población.
- La evidencia sugiere que la financiación de la investigación biomédica, en particular los ensayos bien diseñados, está justificada.
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