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Una base sináptica y de circuito para la descarga corolar en la corteza auditiva

David M Schneider¹, Anders Nelson¹, Richard Mooney²

¹1] Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina 27710, USA [2].

|August 28, 2014

Resumen

Las señales motoras suprimen la actividad de la corteza auditiva antes y durante el movimiento, mediada por neuronas e interneuronas específicas. Esta investigación aclara la base neuronal de la descarga corolar para mejorar la audición y los comportamientos auditivos.

Área de la Ciencia:

La neurociencia es la neurociencia.
La neurociencia auditiva es una neurociencia auditiva.
El control del motor es el control del motor.

Sus antecedentes:

Las regiones sensoriales del cerebro integran señales ambientales con señales motoras para el movimiento.
Las vías de la corteza motora a la corteza auditiva son cruciales para la audición y el comportamiento, pero los mecanismos no están claros.

Objetivo del estudio:

Aclarar los mecanismos sinápticos y de circuitos por los cuales las señales motoras influyen en la actividad auditiva cortical.
Investigar el papel de la descarga corolar relacionada con el motor en el procesamiento auditivo.

Principales métodos:

In vivo grabaciones intracelulares en el comportamiento de ratones.
Experimentos electrofisiológicos y optogenéticos de ganancia y pérdida de función.
Análisis de la actividad neuronal en la corteza auditiva y secundaria motora.

Principales resultados:

Las neuronas excitatorias en la corteza auditiva se suprimen antes y durante el movimiento.
El aumento de la actividad de las interneuronas parvalbumina-positivas contribuye a esta supresión.
Un subconjunto de neuronas de la corteza motora secundaria que se proyectan a la corteza auditiva impulsa estos cambios relacionados con el motor.

Conclusiones:

Proporciona una base sináptica y de circuito para la descarga corolar relacionada con el motor.
Explica cómo los comandos motores influyen en la dinámica cortical auditiva.
Ofrece información sobre los mecanismos que facilitan la audición y los comportamientos guiados auditivos.

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